Control Of Biofilm Infections By Signal Manipulation

PThe medical miracle of antibiotics is being eroded by the emergence and spreadof bacterial drug resistance. This is compounded by the fact that bacterialbiofil... » 

PThe medical miracle of antibiotics is being eroded by the emergence and spreadof bacterial drug resistance. This is compounded by the fact that bacterialbiofilms are believed to be a common cause of persistent infections whenbecause growing in biofilms bacteria are protected from the hosts immuneresponse and from antibiotics. In addition biofilms may spawn systemicinfections by sloughing of planktonic bacteria leading to disseminationbacteremia sepsis and death. The number of patients affected by and dyingfrom what can be considered as a biofilm disease is higher than heart diseaseand cancer combined making medical biofilms the biggest single disease thatthe healthcare system is facing today.BRThis book describes the molecularmechanisms of celltocell communication among bacterial cells in a biofilmthe development of antibiofilm inhibitors like quorumsensing inhibitors andthe use of biofilm inhibitors to prevent and treat bacterial infections inhumans and other animals.P TOCPIntroduction. Bacterial CelltoCellCommunication Quorum Sensing. Detection in Vitro of QuorumSensing Moleculesand Their Inhibitors. QuorumSensing Inhibitory Compounds. MathematicalModeling of QuorumSensing Control in Biofilms. Animal Models Commonly Used toStudy QuorumSensing Inhibitors. In Vivo Studies Inhibiting BiofilmAssociated Bacterial Infections Using QSIs. Quorum Sensing in Streptococci.Ironing Out the Biofilm Problem The Role of Iron in Biofilm Formation.Clinical Wound Healing Using Signal Inhibitors.P «