Combinatorial chemistry and molecular diversity approaches to scientificinquiry and novel product RampD have exploded in the 1990s For example inthe preparation... » 

Combinatorial chemistry and molecular diversity approaches to scientificinquiry and novel product RampD have exploded in the 1990s For example inthe preparation of drug candidates the automated permutational andcombinatorial use of chemical building blocks now allows the generation andscreening of unprecedented numbers of compounds. Drug discovery betterfaster cheaper? Indeed more compounds have been made and screened in the1990s than in the last hundred years of pharmaceutical research. This firstvolume covers i combinatorial chemistry ii combinatorial biology andevolution and iii informatics and related topics. Within each sectionchapters are prepared by experts in the field including for example inSection I Coverage of mixture pools vs. parallel individual compoundsynthesis solution vs. solidphase synthesis analytical tools andautomation. Section II highlights selection strategies and librarybasedevolution phage display peptide and nucleic acid libraries. Section IIIcovers databases and library design high throughput screening codingstrategies vs. deconvolutions intellectual property issues deals andcollaborations and successes to date. «